Good old Plesk.
After an update yesterday, the Plesk milter greylisting has been confused, and returning 451 4.7.1 Service unavailable – try again later for all mail.
Disabling grey listing within Plesk has at least allowed mail to now be delivered while i investigate, though no doubt Parallels will have a fix in the next update.
Server > Mail Settings > Spam Filter Settings.
Untick “Switch on server-wide greylisting spam protection”.